I recently read an article reporting that scientists are seeing evidence of less cancer in patients taking the diabetes drug Metformin, also known as glucophage! Metformin is a very common drug used in the treatment of Type 2 diabetes.
The article states that there is increasing evidence linking Metformin with reduced cancer rates. One study, from Italy, found that type 2 patients who took Metformin had overall lower cancer rates while another study from China found that Metformin actually reverses the increased cancer risk seen in patients with Type 2 diabetes that have low high-density lipoprotein (or HDL, the “good”) cholesterol.
The article goes on to say that although much more research needs to be done, various investigations “strongly suggest the users of Metformin have only about 40% of the expected incidence of breast cancer. That is huge!” reports Dr. Michael Pollack, professor of medicine and oncology at McGill University in Montreal.
The article also quotes Dr. Pamela Goodwin, professor of medicine at the University of Toronto who states that in her studies which were done on mice with aggressive forms of breast cancer, Metformin delayed the development of mammary tumors and in ongoing research by her group, early information provides evidence that women who received Metformin in early-stage breast cancer exhibited significantly less cell proliferation or growth, and significantly increased apoptosis or cancer cell death.
This is greatly significant because people with diabetes are known to have a higher rate of cancer mortality although it is still unclear as to why. Possible causes that have been discussed include the disease itself, greater exposure to insulin (which is a growth hormone), the drugs patients take to control diabetes or to factors such as the increased weight. Unfortunately, increased weight in itself is a risk factor for cancer.
This recent finding about metformin is a major breakthrough for people with diabetes and even for those without diabetes as one researcher suggested a much broader use for the drug. Metformin is a very cheap drug, costing pennies a pill and easily accessible. If it really can decrease the occurrence of cancers by almost 50% - that could be wonderful news.
Of course much more investigation needs to be done, but keep your eyes open for more information.
If you want to read more, see the February 2011 issue of Endocrine News, pg 16 or this article in Diabetes Care.
--Barbara